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Case Studies and Resources

Resources by the Sustainable Chemistry Catalyst

Driving Safer Chemicals Through Alternatives Assessment (2023)
Download: Journal Article

Dangerous Chemicals and the Reduction of Toxic Products in Manufacturing - Joel Tickner and Alicia McCarthy (2022)
Download: Podcast

Combined Application of the Essential-Use and Functional Substitution Concepts:
Accelerating Safer Alternatives (2022)
Download: Journal Article

Scaling Adoption of Alternatives to Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film- Forming Foams (AFFF): Lessons Learned on Needs and Opportunities (2022)
Download: Report

Guidance for Evaluating the Performance of Alternatives: Fit-for-Purpose Performance (2022)
Download: Report

A Critical Review of Alternatives Assessments of Fluorine-Free Alternatives to Per- and Polyfluoroalkyl Substances in Aqueous Film-Forming Foams (2022)
Download: Report

Criteria for Safer: Alternatives to Aqueous Film Forming Foam Products (2022)
Download: Report

The Nexus Between Alternatives Assessment and Green Chemistry: Supporting the Development and
Adoption of Safer Chemicals, Green Chemistry Letters and Reviews (2021)
Download: Journal Article

Lessons from the 2018 International Symposium on Alternatives Assessment: Advances and Reflections
on Practice and Ongoing Needs to Build the Field (2019)
Download: Journal Article

Alternatives Assessment and Informed Substitution: A Global Landscape Assessment of Drivers, Methods, Policies and Needs (2019)
Download: Journal Article

Advancing Alternatives Assessment for Safer Chemical Substitution: A Research and Practice Agenda (2018)
Download: Journal Article

Alternatives Assessment: New Ideas, Frameworks and Policies (2017)
Download: Journal Article

The Applicability of Chemical Alternatives Assessment for Engineered Nanomaterials (2016)
Download: Journal Article

Alternatives Assessment Frameworks: Research Needs for the Informed Substitution of Hazardous
Chemicals (2016)
Download: Journal Article

Resources by the NorthWest Green Chemistry

OR DEQ Roadmap Evaluating Alternatives to Food Packaging Materials Containing PFASs Report (2019)
Download: Report | Supplemental Information

Washington State Alternatives to Five Phthalates of Concern to Puget Sound Report (2018)
Download: Report | Supplemental Information

Emerald Corridor Green Chemistry & Engineering Roadmap 2018–2023 (2018)
Download: Report

Product Innovation and Sustainability Mapping (PrISM) (2018)
Download: Supplemental Information

Washington State Antifouling Boat Paint Alternatives Assessment Report (2017)
Download: Report | Supplemental Information

Resource by the Washington State Department of Ecology

Safer Chemicals for Manufacturers (2024)

Product manufacturers are uniquely positioned to select safer chemicals and design more sustainable products. Manufacturers can achieve this by:

  • Supporting supply chain transparency.
  • Identifying toxic chemicals for replacement.
  • Switching to less toxic chemicals.
  • Certifying their products.

Learn how manufacturers can assess their current products, formulate or reformulate their products using safer chemicals, and how to achieve third-party certification.

Visit Website

Resource by the UNEP

Global Framework on Chemicals - For a Planet Free of Harm from Chemicals and Waste (2023)

The new Global Framework on Chemicals, adopted by the ICCM5 in Bonn in 2023, provides a vision for a planet free of harm from chemicals and waste, for a safe, healthy and sustainable future – where industry and private sectors are strategic actors to foster innovation, move towards sustainable business models and drive change. It is backed up by a High-Level Declaration that provides the political drive for its fast implementation and reminds stakeholders commitment to actively promote and support transitions to circular economies.

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Other Resources


ECHA CHEM is ECHA’s new public chemicals database launched in early 2024. Initially, it includes data that companies have submitted in their REACH registrations. Over the coming years, ECHA will gradually transfer the data it makes publicly available from their current location (Search for chemicals) to ECHA CHEM. 

EU’s Safer Chemicals Podcast

Listen to expert views on chemical safety in the EU and join the scientific discussion on key topics including microplastics, glyphosate, endocrine disruptors, chemicals used in tattoo inks, and much more.

Assessment of Alternatives Training

This comprehensive introductory training focuses on essential topics for an assessment of alternatives to support informed substitution. The training has six sessions and is publicly available on YouTube.

OECD Substitution and Alternatives Assessment Toolbox

Includes a detailed compilation of tools, frameworks, case studies, and policies relevant to chemical substitution and alternatives assessments.

OSHA Transitioning to Safer Chemicals

Contains a step-by-step framework and guide with links to resources to support companies in transitioning to safer chemicals in their firms.

Massachusetts Toxics Use Reduction Institute

Hosts a range of educational and technical resources on alternatives assessment and substitution, including databases, case studies, reports, and educational materials.

Interstate Chemicals Clearinghouse

View the IC2 alternatives assessment library here.

Includes a searchable database of state chemicals policies, chemical hazard assessments, lists of chemicals of concern and the IC2 alternatives assessment guide – a comprehensive assessment framework.


European initiative that includes model tools, lists of chemicals and endpoints of concern, case studies and training resources.